Location: US 45 and McCullough Blvd, Tupelo After the 178 split we’re a mile from Interstate 22/US 78. Location: US 45 and I-22, Tupelo Follow I-22/US 78 east to Birmingham, Ala. Location: US 45 and I-22, Tupelo Exit for I-22/US 78 west to Memphis, Tenn.  N to MS-145, S to MS-6  E to MS-178/MS-363, W to … Continue reading U.S. Route 45, MS-178 to I-22/US-78